Sure.
Last season, the Spring floods when the river flowed over its banks caused buildings to shut down or even be destroyed, it caused deaths as people were flooded from their homes, I think i even saw one person who was momentarily out of a job. It caused sickness, such as pneumonia, and many of the problems have carried over into this season, such as the ruined buildings.
The curse is even bigger, I think. There are two quests being run surrounding the slabs, as well as city-wide riots, the effects of the curse on people (nightmares, fainting, illness) and the pond of curing water which are available to investigate. There is the recurrence of the symbols from murders of seasons past (just exposed in the Quest thread from the 18th), and the ominous message about rewards for surviving the curse which promises that it will affect us for seasons to come. And then there's the mysterious ship off of the coast that contains those creepy sailors, which is a prompt open to anyone. That one may or may not be related, I'm not sure.
Overall, I think the curse is pretty all-encompassing as far as its effect on the city and its people, and will likely have an even larger impact on the community than many of the past events.
I'm rather excited, in case you couldn't tell.